Evidence supported that sperm quality declination in men is significant from the last decades.
Parental age and sperm quality are two influencing male factors that interfere with IVF success.
The IVF is an assisted reproductive technology used as a therapeutic solution for couples who are facing difficulty to conceive normally.
The sperm parameters like poor sperm motility and structural deformity interfere with fertilization.
The contribution of male gametes is 50% of the embryo genome.
A clinical trial reported that the malefactors significantly impact ART outcomes.
The sperm’s rapid progressive motility affects the IVF fertilization rate.
This study finding also indicated that oligospermia is a common issue with increasing parental age.
A transfer at the cleaved embryo stage is a better option for severe oligospermia as the blastocyst formation rate is significantly reduced.
Researchers are also working on the quantification of free sperm DNA to optimize the selection of male gametes for improving ART results.
In general semen, the test is performed for analysing the male sperm count.
Male with low sperm counts (< 5 million motile sperm) are facing problems to achieve pregnancies.
Finding defects in semen analysis leads to a difficult prognosis.
Abnormal morphology interfere the IVF success.
Some of these men are also facing difficulty in fertilizing eggs.
However, not all of them are having the same issue.
In such cases, often IVF and ICSI prescribe to assist in conceiving along with antioxidant therapy.
Male individuals with borderline morphology often get improvement with Antioxidant therapy alone.
But almost 3-6 months of therapy is required to show just a small morphological improvement.
Certain tests like Tunnel, Comet, and SCSA Assays are performed to analyze the Sperm DNA fragmentation tests.
The contribution of sperm DNA to embryo quality is an important area of research. But the reliability and reproducibility of these tests are still under consideration.
Antioxidant therapy and donor sperm are two recommended options in case of finding a high sperm DNA fragmentation index.
The IVF success rate is quite high to overcome the male factor infertility.
Reproductive Specialists can guide a couple based on the initial test reports.
In some cases, consultation with a reproductive urologist is also required for determining the best possible treatment option.
